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Case Overview

Case Overview

History of Present Illness
Symptoms began in 2020 with a now-familiar pattern: nausea and abdominal bloating rising after meals, typically within 30-120 minutes. Symptoms began during COVID/family arguing and after a case of (self-diagnosed) dengue fever. Early work-ups showed bile reflux on endoscopy (with a negative CT). He experiences occasional vertigo in the evenings and waves of pain lasting ~45 minutes (always accompanying nausea), and has psoriasis on his forehead. Over time he noticed that nausea and bloating correlate ~1:1.

Through extensive self-experimentation he identified three decisive meal variables: size, speed, and fat content. Meals over ~500–600 kcal, fast eating, or >7g fat per 400cal consistently triggered a post-prandial wave; in contrast, splitting meals into smaller servings and chewing slowly could prevent a flare altogether. He documented this repeatedly, and on several occasions noted immediate improvement simply by pacing the meal and/or finishing with a walk. When he drifted from these rules, symptoms returned. He learned that dairy is a trigger, and avoids it completely.

Acid support (betaine HCl) was tried early and repeatedly, but each structured trial made things worse - more gas/burping and sharper post-prandial nausea. In late October 2024 a high-dose HCl experiment culminated in the “worst nausea of his life,” and he abandoned the approach. Since then he has treated HCl as contraindicated for him.

He briefly tried EMDR and Somatic Experiencing. Although a session could coincide with a short window of feeling better, he disliked the modalities and stopped quickly. By contrast, movement proved to be a potent, repeatable intervention: gym sessions and even brisk walks could collapse an active flare quickly. He has many entries where a workout immediately improved nausea from a moderate/high level to minimal. The same “movement effect” shows up during high-novelty days: he had some of his best health at amusement parks, with little to no nausea despite imperfect food choices. Together these observations suggest a strong autonomic component superimposed on food mechanics.

The next major turning point was antimicrobial therapy. Beginning in late 2024 and continuing through 2025, structured cycling of antimicrobials (berberine, oregano, allicin, neem, and Biocidin) produced a clear, durable reduction in gas, bloating, and nausea. When he drifts off antimicrobials (supply issues, travel), nausea tends to worsen. In parallel, pre-meal digestive enzymes and digestive bitters became essential tools. These have remained in place even when he simplifies the rest of his supplement stack.

A more recent but important lever is vagal nerve stimulation. Consistent sessions with a VaguStim device (plus simple humming drills and cold showers) reduced the frequency and intensity of post-prandial waves. This effect, combined with the movement/novelty effect, maps to an autonomic component to his symptom loop.

Supplement format also mattered. Taking too many pills throughout the day was stressful and made him identify with his illness, exacerbating symptoms. Switching to gummies was easier, but correlated with more gas. Switching to liquids/chewables and pruning non-essentials improved tolerance. In early 2025 he developed swallowing/pill-sticking episodes that could themselves trigger nausea, so he now prioritizes smaller capsules or liquid forms.

Contextual modifiers remain important. Travel is the most consistent destabilizer: larger/fatty meals, sleep loss, and skipping cornerstone habits often cluster on travel days and precipitate several-day setbacks. Conversely, predictable food environments (e.g., closely controlled private chef meals) and structured routines (consistent supplements, movement, VaguStim) produce his longest stretches of near-normal days. He also noted a few adjuncts with situational benefit (e.g., a wearable neuromodulation band and, on one morning, caffeine making him feel “normal”), but none rival the foundational regimen above. He continues to slowly lose weight because it's challenging to intake enough calories between his meal timing constraints, low-fat meals, and overall 'food-makes-me-feel-worse' pattern.

Case Overview

History of Present Illness
Symptoms began in 2020 with a now-familiar pattern: nausea and abdominal bloating rising after meals, typically within 30-120 minutes. Symptoms began during COVID/family arguing and after a case of (self-diagnosed) dengue fever. Early work-ups showed bile reflux on endoscopy (with a negative CT). He experiences occasional vertigo in the evenings and waves of pain lasting ~45 minutes (always accompanying nausea), and has psoriasis on his forehead. Over time he noticed that nausea and bloating correlate ~1:1.

Through extensive self-experimentation he identified three decisive meal variables: size, speed, and fat content. Meals over ~500–600 kcal, fast eating, or >7g fat per 400cal consistently triggered a post-prandial wave; in contrast, splitting meals into smaller servings and chewing slowly could prevent a flare altogether. He documented this repeatedly, and on several occasions noted immediate improvement simply by pacing the meal and/or finishing with a walk. When he drifted from these rules, symptoms returned. He learned that dairy is a trigger, and avoids it completely.

Acid support (betaine HCl) was tried early and repeatedly, but each structured trial made things worse - more gas/burping and sharper post-prandial nausea. In late October 2024 a high-dose HCl experiment culminated in the “worst nausea of his life,” and he abandoned the approach. Since then he has treated HCl as contraindicated for him.

He briefly tried EMDR and Somatic Experiencing. Although a session could coincide with a short window of feeling better, he disliked the modalities and stopped quickly. By contrast, movement proved to be a potent, repeatable intervention: gym sessions and even brisk walks could collapse an active flare quickly. He has many entries where a workout immediately improved nausea from a moderate/high level to minimal. The same “movement effect” shows up during high-novelty days: he had some of his best health at amusement parks, with little to no nausea despite imperfect food choices. Together these observations suggest a strong autonomic component superimposed on food mechanics.

The next major turning point was antimicrobial therapy. Beginning in late 2024 and continuing through 2025, structured cycling of antimicrobials (berberine, oregano, allicin, neem, and Biocidin) produced a clear, durable reduction in gas, bloating, and nausea. When he drifts off antimicrobials (supply issues, travel), nausea tends to worsen. In parallel, pre-meal digestive enzymes and digestive bitters became essential tools. These have remained in place even when he simplifies the rest of his supplement stack.

A more recent but important lever is vagal nerve stimulation. Consistent sessions with a VaguStim device (plus simple humming drills and cold showers) reduced the frequency and intensity of post-prandial waves. This effect, combined with the movement/novelty effect, maps to an autonomic component to his symptom loop.

Supplement format also mattered. Taking too many pills throughout the day was stressful and made him identify with his illness, exacerbating symptoms. Switching to gummies was easier, but correlated with more gas. Switching to liquids/chewables and pruning non-essentials improved tolerance. In early 2025 he developed swallowing/pill-sticking episodes that could themselves trigger nausea, so he now prioritizes smaller capsules or liquid forms.

Contextual modifiers remain important. Travel is the most consistent destabilizer: larger/fatty meals, sleep loss, and skipping cornerstone habits often cluster on travel days and precipitate several-day setbacks. Conversely, predictable food environments (e.g., closely controlled private chef meals) and structured routines (consistent supplements, movement, VaguStim) produce his longest stretches of near-normal days. He also noted a few adjuncts with situational benefit (e.g., a wearable neuromodulation band and, on one morning, caffeine making him feel “normal”), but none rival the foundational regimen above. He continues to slowly lose weight because it's challenging to intake enough calories between his meal timing constraints, low-fat meals, and overall 'food-makes-me-feel-worse' pattern.
What has helped the most?
✓ Small, low-fat meals eaten slowly (private chef providing closely controlled macros helps immensely with this!)
✓ Antimicrobials, digestive bitters/enzymes.
✓ Daily exercise.
✓ Vagal tone stimulation (device, humming, breathing).
✓ Socializing.
✓ Empowered mindset, getting out of the house, not ruminating on symptoms.
What has worsened symptoms?
☓ Larger meals (>500cal), high fat loads (>7g/400cal), eating quickly.
☓ Dairy.
☓ Betaine HCl.
☓ Alcohol, sleep loss, travel.
☓ Generally taking too many supplements thought the day.
☓ New swallowing/esophageal sticking episodes.
☓ Gummy supplements and probiotics caused intense gas/bloating.
☓ Isolation, stress, staying inside on couch.
Notable results?
✓ Bile reflux on EGD.
✓ Immune pattern: Low WBC/neutrophils, high lymphocytes. Consistent EBV reactivation and positive Hepatitis A and Herpesvirus 6.
✓ Autoimmunity pattern: ANA positive (highest 1:680/speckled, sometimes 1:40 or negative).
✓ Mucosal immune activation: Cyrex Array 14 showed widespread high IgA/IgM reactivity to gliadin, caseins, soy, corn, LPS, BBB proteins, and zonulin/occludin; secretory IgA extremely high. Cyrex Array 14 has tracked closely with his symptoms: always very high, but better when he's feeling better and worse when he's feeling worse.
✓ Barrier dysfunction: Stool zonulin, calprotectin, and β-glucuronidase sometimes mildly elevated.
✓ Cytokine pattern: IL-18 markedly high, IFN-γ high, RANTES low.
✓ Low cholesterol.

☓ Normal abdominal CT.
☓ Normal gastric emptying study.

Timeline

Timeline

Timeline

2020–2021: Early Course

● Mid-2020: First mild nausea episodes, lasting 1–2 hours a day. Anti-nausea medications ineffective.

● Late 2020–early 2021: Symptoms remitted for several months.

● Mid–late 2021: Nausea gradually returned, 3–5 days per week, up to 4 hours daily. Multiple online consults suggested little actionable advice. Labs, thyroid testing, and initial bloodwork were normal.

2022: Emerging Pattern

● Early 2022: Symptoms abated again for ~4 months.

● Mid–late 2022: Relapse with moderate-to-severe daily nausea. Learned that dairy is a trigger, started avoiding completely.

2023: Major Escalation

● Early 2023:

  • Gluten-free diet (7 months) ineffective. Cut onions, spicy foods, carbonated drinks with no relief.

  • PPIs briefly helpful then stopped working. Sucralfate ineffective. NSAID avoidance modestly helpful.

  • Endoscopy: bile reflux; biopsy negative.

● Mid 2023: Positive SIBO breath test.

● Summer 2023: Multiple food sensitivities confirmed (gluten, dairy, soy, corn, nuts, eggs, tomato).

● Fall 2023: Rifaximin trial worsened symptoms; low-FODMAP diet worsened symptoms. Multiple consults in different regions.

● Late 2023: Began connecting symptoms to meal size, fat content, and eating speed. >500cal meals or >7g fat per 400cal reliably provoked nausea/bloating. Gastric emptying test negative; HIDA scan showed impaired gallbladder emptying (22%). CT abdomen negative.

2024: Pattern Recognition & Interventions

● Early 2024:

  • Betaine HCl trials consistently worsened nausea and bloating; discontinued.

  • Secretory IgA fluctuated (extremely high to low).

● Spring 2024:

  • Organic acid abnormalities (fumaric, lactic, methylcitric, ethylmalonic) → mitochondrial stress.

  • EBV and HHV-6 IgG elevated.

● Summer 2024

  • Brief trials of EMDR and Somatic Experiencing, which sometimes decreased nausea temporarily but he disliked the process and stopped.

  • Nordic labs: Enterobacter and B. fragilis overgrowth, macrolide-resistant H. pylori genes.

  • Antimicrobial cycling (berberine, oregano, allicin, neem, Biocidin) began. Clear improvement in gas and bloating.

  • Digestive enzymes and bitters emerged as essential: produced relief within 15 minutes, consistently documented.

  • High-novelty, high-movement days (e.g., full-day amusement park visits) correlated with some of his best days ever - nearly absent nausea despite less ideal food.

● Fall 2024:

  • Strong reinforcement of the “big three”: meal size, meal speed, fat load. Splitting meals, eating slowly, and reducing fat intake transformed outcomes.

  • Exercise repeatedly shown to abort flares: gym workout (usually weights) or even brisk walks often rapidly reduced nausea.

2025: Consolidation & Refinement

● Jan–Feb:

  • Supplement overload worsened nausea and bloating; simplifying stack and switching to liquids/chewables improved tolerance.

  • Began low-dose naltrexone (modest benefit).

  • Antimicrobials, enzymes, and bitters established as non-negotiable parts of regimen.

  • Gas worsened at times with gummies or certain supplements. Simplification improved control.

  • Taking too many supplements throughout the day. Simplifying his routine helped literally overnight.

● Mar:

  • GIMap: very high sIgA, elevated β-glucuronidase, moderately high calprotectin and zonulin. Clear barrier dysfunction and mucosal immune activation.

  • Viral panel reconfirmed EBV reactivation with positive Hepatitis A and Herpesvirus 6.

  • Noted new swallowing/esophageal issue: pills and occasional food getting stuck in throat, sometimes triggering nausea.

● Spring–Summer:

  • Structured program: small (~400–450 kcal) slow meals, fat restriction, consistent antimicrobials, digestive support, daily exercise, and VaguStim vagal nerve stimulation 2–3×/day.

  • Added humming and cold showers as adjunct vagal tone practices.


● Summer travel: predictably worsened symptoms.


● Fall 2025:

  • Ordered a second VaguStim unit to maintain daily adherence.

Key Cross-Cutting Themes

● Big Three Levers: Meal size, speed, and fat content remain the strongest determinants of symptom burden.

● Movement/Novelty Effect: Walking, exercise, socializing, and stimulating new environments consistently reduce or abolish nausea.

● Treatment backbone: Antimicrobials, digestive enzymes/bitters, and vagal nerve stimulation.

● Outstanding Issues: Chronic neutropenia, EBV/HHV-6 reactivation, Th2 immune skew, gallbladder impairment, new esophageal swallowing dysfunction