
Know the story.
Explore the history, labs, and data behind this medical mystery

What has helped the most?
✓ Small, low-fat meals eaten slowly (private chef providing closely controlled macros helps immensely with this!)
✓ Antimicrobials, digestive bitters/enzymes.
✓ Daily exercise.
✓ Vagal tone stimulation (device, humming, breathing).
✓ Socializing.
✓ Empowered mindset, getting out of the house, not ruminating on symptoms.
What has worsened symptoms?
☓ Larger meals (>500cal), high fat loads (>7g/400cal), eating quickly.
☓ Dairy.
☓ Betaine HCl.
☓ Alcohol, sleep loss, travel.
☓ Generally taking too many supplements thought the day.
☓ New swallowing/esophageal sticking episodes.
☓ Gummy supplements and probiotics caused intense gas/bloating.
☓ Isolation, stress, staying inside on couch.
Notable results?
✓ Bile reflux on EGD.
✓ Immune pattern: Low WBC/neutrophils, high lymphocytes. Consistent EBV reactivation and positive Hepatitis A and Herpesvirus 6.
✓ Autoimmunity pattern: ANA positive (highest 1:680/speckled, sometimes 1:40 or negative).
✓ Mucosal immune activation: Cyrex Array 14 showed widespread high IgA/IgM reactivity to gliadin, caseins, soy, corn, LPS, BBB proteins, and zonulin/occludin; secretory IgA extremely high. Cyrex Array 14 has tracked closely with his symptoms: always very high, but better when he's feeling better and worse when he's feeling worse.
✓ Barrier dysfunction: Stool zonulin, calprotectin, and β-glucuronidase sometimes mildly elevated.
✓ Cytokine pattern: IL-18 markedly high, IFN-γ high, RANTES low.
✓ Low cholesterol.
☓ Normal abdominal CT.
☓ Normal gastric emptying study.
2020–2021: Early Course
● Mid-2020: First mild nausea episodes, lasting 1–2 hours a day. Anti-nausea medications ineffective.
● Late 2020–early 2021: Symptoms remitted for several months.
● Mid–late 2021: Nausea gradually returned, 3–5 days per week, up to 4 hours daily. Multiple online consults suggested little actionable advice. Labs, thyroid testing, and initial bloodwork were normal.
2022: Emerging Pattern
● Early 2022: Symptoms abated again for ~4 months.
● Mid–late 2022: Relapse with moderate-to-severe daily nausea. Learned that dairy is a trigger, started avoiding completely.
2023: Major Escalation
● Early 2023:
Gluten-free diet (7 months) ineffective. Cut onions, spicy foods, carbonated drinks with no relief.
PPIs briefly helpful then stopped working. Sucralfate ineffective. NSAID avoidance modestly helpful.
Endoscopy: bile reflux; biopsy negative.
● Mid 2023: Positive SIBO breath test.
● Summer 2023: Multiple food sensitivities confirmed (gluten, dairy, soy, corn, nuts, eggs, tomato).
● Fall 2023: Rifaximin trial worsened symptoms; low-FODMAP diet worsened symptoms. Multiple consults in different regions.
● Late 2023: Began connecting symptoms to meal size, fat content, and eating speed. >500cal meals or >7g fat per 400cal reliably provoked nausea/bloating. Gastric emptying test negative; HIDA scan showed impaired gallbladder emptying (22%). CT abdomen negative.
2024: Pattern Recognition & Interventions
● Early 2024:
Betaine HCl trials consistently worsened nausea and bloating; discontinued.
Secretory IgA fluctuated (extremely high to low).
● Spring 2024:
Organic acid abnormalities (fumaric, lactic, methylcitric, ethylmalonic) → mitochondrial stress.
EBV and HHV-6 IgG elevated.
● Summer 2024
Brief trials of EMDR and Somatic Experiencing, which sometimes decreased nausea temporarily but he disliked the process and stopped.
Nordic labs: Enterobacter and B. fragilis overgrowth, macrolide-resistant H. pylori genes.
Antimicrobial cycling (berberine, oregano, allicin, neem, Biocidin) began. Clear improvement in gas and bloating.
Digestive enzymes and bitters emerged as essential: produced relief within 15 minutes, consistently documented.
High-novelty, high-movement days (e.g., full-day amusement park visits) correlated with some of his best days ever - nearly absent nausea despite less ideal food.
● Fall 2024:
Strong reinforcement of the “big three”: meal size, meal speed, fat load. Splitting meals, eating slowly, and reducing fat intake transformed outcomes.
Exercise repeatedly shown to abort flares: gym workout (usually weights) or even brisk walks often rapidly reduced nausea.
2025: Consolidation & Refinement
● Jan–Feb:
Supplement overload worsened nausea and bloating; simplifying stack and switching to liquids/chewables improved tolerance.
Began low-dose naltrexone (modest benefit).
Antimicrobials, enzymes, and bitters established as non-negotiable parts of regimen.
Gas worsened at times with gummies or certain supplements. Simplification improved control.
Taking too many supplements throughout the day. Simplifying his routine helped literally overnight.
● Mar:
GIMap: very high sIgA, elevated β-glucuronidase, moderately high calprotectin and zonulin. Clear barrier dysfunction and mucosal immune activation.
Viral panel reconfirmed EBV reactivation with positive Hepatitis A and Herpesvirus 6.
Noted new swallowing/esophageal issue: pills and occasional food getting stuck in throat, sometimes triggering nausea.
● Spring–Summer:
Structured program: small (~400–450 kcal) slow meals, fat restriction, consistent antimicrobials, digestive support, daily exercise, and VaguStim vagal nerve stimulation 2–3×/day.
Added humming and cold showers as adjunct vagal tone practices.
● Summer travel: predictably worsened symptoms.
● Fall 2025:
Ordered a second VaguStim unit to maintain daily adherence.
Key Cross-Cutting Themes
● Big Three Levers: Meal size, speed, and fat content remain the strongest determinants of symptom burden.
● Movement/Novelty Effect: Walking, exercise, socializing, and stimulating new environments consistently reduce or abolish nausea.
● Treatment backbone: Antimicrobials, digestive enzymes/bitters, and vagal nerve stimulation.
● Outstanding Issues: Chronic neutropenia, EBV/HHV-6 reactivation, Th2 immune skew, gallbladder impairment, new esophageal swallowing dysfunction